宫衡
生物工程专业：博士生导师/硕士生导师
生物学专业：硕士生导师
生物与医药专业（生物工程领域）：博士生导师/硕士生导师
江苏镇江人，博士、教授。1985至89 年，于无锡轻工业学院（现改名江南大学），获发酵工程工学学士学位；并于1994在该校获发酵工程工学博士学位。1995年至今，在beat365体育官网平台从事教学和科研工作，期间于2000年至02年于日本大阪大学生物工程国际交流中心进行博士后研究。教学方面，主讲课程《发酵工程》为国家精品课程。研究方面主要从事微生物产品的开发，实施的多项产品技术水平处于国内领先；其中生物法1,3-丙二醇生产技术建成了国内首套万吨级的产业化装置。
研究方向：
1、 发酵过程工程：
结合微生物营养需求与产物代谢的特点，通过过程优化与放大，以实现大规模水平上发酵过程的稳定与高效。
2、 应用分子生物学：
利用生物信息学和现代分子生物学方法手段，研究微生物的代谢调节及产物合成的机制。
3、 生物检测
主要利用表面增强拉曼光谱（SRES）实现生物样品的快速检测。
代表性论文（*通讯作者）：
1. Bao, W., Wei, R., Liu, X., Dong, S., Chen, T., Fu, S., and Gong, H.*, Regulation of Pyruvate Formate Lyase-Deficient Klebsiella pneumoniae for Efficient 1,3-Propanediol Bioproduction. Curr Microbiol, 2020. 77(1): p. 55-61.
2. Xu, D., Jia, Z., Zhang, L., Fu, S., and Gong, H.*, Analysis of the Growth and Metabolites of a Pyruvate Dehydrogenase Complex- Deficient Klebsiella pneumoniae Mutant in a Glycerol-Based Medium. J Microbiol Biotechnol, 2020. 30(5): p. 753-761.
3. Zhang, L., Bao, W., Wei, R., Fu, S., and Gong, H.*, Inactivating NADH:quinone oxidoreductases affects the growth and metabolism of Klebsiella pneumoniae. Biotechnol Appl Biochem, 2018. 65(6): p. 857-864.
4. Zhang, Y., Jia, Z., Lin, J., Xu, D., Fu, S., and Gong, H.*, Deleting pck improves growth and suppresses by-product formation during 1,3-propanediol fermentation by Klebsiella pneumoniae. J Appl Microbiol, 2017. 123(3): p. 678-687.
5. Huang, Y., Gu, J., Xiang, G., Xu, J., Fu, S., and Gong, H.*, Detection of total protein in milk using phosphomolybdic acid-mediated surface-enhanced Raman spectroscopy. Journal of Raman Spectroscopy, 2016. 47(3): p. 277-282.
6. Jiang, X., Zhu, C., Lin, J., Li, J., Fu, S., and Gong, H.*, Vector promoters used in Klebsiella pneumoniae. Biotechnol Appl Biochem, 2016. 63(5): p. 734-739.
7. Lin, J., Zhang, Y., Xu, D., Xiang, G., Jia, Z., Fu, S., and Gong, H.*, Deletion of poxB, pta, and ackA improves 1,3-propanediol production by Klebsiella pneumoniae. Appl Microbiol Biotechnol, 2016. 100(6): p. 2775-84.
8. Li, M., Chen, J., Xu, J., Fu, S., and Gong, H.*, Determination of Lactose in Milk by Raman Spectroscopy. Analytical Letters, 2015. 48(8): p. 1333-1340.
9. Zhu, C., Jiang, X., Zhang, Y., Lin, J., Fu, S., and Gong, H.*, Improvement of 1,3-propanediol production in Klebsiella pneumoniae by moderate expression of puuC (encoding an aldehyde dehydrogenase). Biotechnol Lett, 2015. 37(9): p. 1783-90.
10. Cui, Y.L., Zhou, J.J., Gao, L.R., Zhu, C.Q., Jiang, X., Fu, S.L., and Gong, H.*, Utilization of excess NADH in 2,3-butanediol-deficient Klebsiella pneumoniae for 1,3-propanediol production. J Appl Microbiol, 2014. 117(3): p. 690-8.
11. Gao, L.R., Jiang, X., Fu, S.L., and Gong, H.*, In silico identification of potential virulence genes in 1,3-propanediol producer Klebsiella pneumonia. J Biotechnol, 2014. 189(10): p. 9-14.
12. Zhong, Z.H., Liu, L.F., Zhou, J.J., Gao, L.R., Xu, J.J., Fu, S.L., and H., G*. Influences of 3-hydroxypropionaldehyde and lactate on the production of 1,3-propanediol by Klebsiella pneumoniae. Bioresources and Bioprocessing, 2014. 1, DOI: 10.1186/s40643-014-0002-z.
13. Xiang, G., Li, J., Duan, J., Shao, F., Xu, J., Fu, S., and Gong, H.*, Acceleration effect of amino acid supplementation on glycerol assimilation by Escherichia coli in minimal medium. Biotechnol Lett, 2013. 35(9): p. 1495-500.
14. Xu, J., Turner, J.W., Idso, M., Biryukov, S.V., Rognstad, L., Gong, H., Trainer, V.L., Wells, M.L., Strom, M.S., and Yu, Q., In situ strain-level detection and identification of Vibrio parahaemolyticus using surface-enhanced Raman spectroscopy. Anal Chem, 2013. 85(5): p. 2630-7.
15. Zhang, L., Xu, J., Mi, L., Gong, H., Jiang, S., and Yu, Q., Multifunctional magnetic-plasmonic nanoparticles for fast concentration and sensitive detection of bacteria using SERS. Biosensors & Bioelectronics, 2012. 31(1): p. 130-6.
16. Xu, J., Kvasnicka, P., Idso, M., Jordan, R.W., Gong, H., Homola, J., and Yu, Q., Understanding the effects of dielectric medium, substrate, and depth on electric fields and SERS of quasi-3D plasmonic nanostructures. Opt Express, 2011. 19(21): p. 20493-505.
17. Xu, J., Zhang, L., Gong, H., Homola, J., and Yu, Q., Tailoring plasmonic nanostructures for optimal SERS sensing of small molecules and large microorganisms. Small, 2011. 7(3): p. 371-6.
18. Xu, J.J., Guan, P., Kvasnicka, P., Gong, H., Homola, J., and Yu, Q.M., Light Transmission and Surface-Enhanced Raman Scattering of Quasi-3D Plasmonic Nanostructure Arrays with Deep and Shallow Fabry-Perot Nanocavities. Journal of Physical Chemistry C, 2011. 115(22): p. 10996-11002.
19. Yu, Q., Braswell, S., Christin, B., Xu, J., Wallace, P.M., Gong, H., and Kaminsky, D., Surface-enhanced Raman scattering on gold quasi-3D nanostructure and 2D nanohole arrays. Nanotechnology, 2010. 21(35): p. 355301.
发明专利：
1. 宫衡, 陈天宇, and 付水林, 一种调控生长速度筛选1,3-丙二醇生产菌株的方法.中国发明专利:2020104167201
2. 宫衡, 刘旭霞, and 付水林, 一种可靠、稳定生产多元醇的方法.中国发明专利:2020105259662
3. 宫衡, 魏仁全, and 付水林, 一种降低1,3-丙二醇生产过程中副产物的方法.中国发明专利:2020107925827
4. 宫衡, 暴文静, and 付水林, 强化丙酮酸脱氢酶途径高效生产1,3-丙二醇的方法.中国发明专利:2019105577535
5. 宫衡, 张利娟, and 傅水林, 一种高效合成多元醇的新方法.中国发明专利:2018108343046
6. 宫衡, 徐丹凤, and 傅水林, 一种同时生物合成1,3‑丙二醇和乙偶姻的新方.中华人民共和国国家知识产权局:2017102753432
7. 宫衡, 张永强, and 傅水林, 一种改进1,3-丙二醇生物合成的方法.中国发明专利:
8. 宫衡, 黄英钊, and 付水林, 一种快速检测牛奶中总蛋白的方法.中国发明专利:201510181955.6
9. 宫衡, 林杰, and 付水林, 一种通过降低副产物乙酸高效生产1,3-丙二醇的方法中国发明专利: 201510621014.X
联系方式：
地点：上海市徐汇区梅陇路130号，beat365体育官网平台实验五楼211
邮编：200237
Tel： 021-64253007
Email：gongheng@ecust.edu.cn