陈显军 博士   

生物工程专业：博士生导师

生物反应器工程国家重点实验室固定成员

光遗传学与合成生物学交叉学科研究中心核心成员

上海市细胞代谢光遗传学技术前沿科学研究基地成员

个人简介

2009年6月本科毕业于beat365体育官网平台生物技术专业，获理学学士学位。2015年6月博士毕业于beat365体育官网平台药学院化学生物技术与工程专业，获工学博士学位。2015年7月开始从事beat365体育官网平台药学博士后研究，现任生物反应器工程国家重点实验室PI。迄今已在Nature Biotechnology (2019, Cover story; 2021), Nature Methods、Nature Chemical Biology、Cell Research、Nature Communications、Nucleic Acids Research等国际权威期刊发表SCI论文多篇，编写英文著作Curr Protoc Chem Biol 1个章节。已申请多项中国发明专利（授权2项）和国际PCT专利（分别授权2项美国、日本和欧洲发明专利）。主持包括国家自然科学基金面上项目、青年基金、上海市自然科学基金在内的多项国家与省部级基金项目，先后入选国家高层次特殊支持计划、中国科协青年人才托举工程项目、上海市青年科技启明星，获得上海市生物化学与分子生物学学会第二届“青年新锐奖”。

研究方向

1、新型光遗传学技术的开发与应用

2、生物大分子荧光标记技术开发与应用

研究生招生

团队（杨弋教授领衔的光遗传学与合成生物学交叉学科研究中心）研究对象涉及基因、蛋白质、细菌、哺乳动物细胞、线虫、斑马鱼、果蝇和小鼠，研究领域涉及细胞生物学、生物化学与分子生物学、合成生物学、光遗传学、化学遗传学、化学生物学等。本团队热忱欢迎有志于从事光遗传学、合成生物学、化学生物学研究的同学加盟本团队。

发表论文

(1) Renmei Liu^#, Jing Yang^#, Jing Yao, Zhou Zhao, Dr Wei He, Ni Su, Zeyi Zhang, Chenxia Zhang, Zhuo Zhang, Haibo Cai, Linyong Zhu, Yuzheng Zhao, Shu Quan, Xianjun Chen*, Yi Yang*, Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins, Nature Biotechnology, 2022, online.

(2) Kaiyi Huang^#, Xianjun Chen^#, Chunyan Li, Qianqian Song, Huiwen Li, Linyong Zhu*, Yi Yang*, Aiming Ren*, Structure-based investigation of fluorogenic Pepper aptamer, Nature Chemical Biology, 2021, 17, 1289-1295.

 (3) Ting Li^#, Xianjun Chen^#, Yajie Qian, Jiawei Shao, Xie Li, Shuning Liu, Linyong Zhu, Yuzheng Zhao, Haifeng Ye* & Yi Yang*, A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nature Communications, 2021, 12, 615.

(4) Xinyu Hou, Chenting Shou, Muye He, Jiajun Xu, Yi Cheng, Zeting Yuan, Minbo Lan, Yuzheng Zhao, Yi Yang, Xianjun Chen*, Feng Gao*, A combination of LightOn gene expression system and tumor microenvironment-responsive nanoparticle delivery system for targeted breast cancer therapy. Acta Pharmaceutica Sinica B, 2020, 10, 1741-1753.

(5) Xie Li, Changcheng Zhang, Xiaopei Xu, Jun Miao, Jing Yao, Renmei Liu, Yuzheng Zhao, Xianjun Chen*, Yi Yang*. A single-component light sensor system allows highly tunable and direct activation of gene expression in bacterial cells. Nucleic acids research, 2020, 48, e33.

(6) Jiajun Xu, Muye He, Xinyu Hou,Yan Wang,Chenting Shou, Xiaoran Cai, Zeting Yuan, Yu Yin, Minbo Lan, Kaiyan Lou, Yuzheng Zhao, Yi Yang, Xianjun Chen*, Feng Gao*, Safe and Efficacious Diphtheria Toxin-Based Treatment for Melanoma: Combination of a Light-On Gene-Expression System and Nanotechnology. Molecular pharmaceutics, 2020, 17 (1), 301-315.

(7) Xianjun Chen^#, Dasheng Zhang^#, Ni Su^#, Bingkun Bao, Xin Xie, Fangting Zuo, Lipeng Yang, Hui Wang, Li Jiang, Qiuning Lin, Mengyue Fang, Ningfeng Li, Xin Hua, Zhengda Chen, Chunyan Bao, Jinjin Xu, Wenli Du, Lixin Zhang, Yuzheng Zhao, Linyong Zhu*, Joseph Loscalzo, Yi Yang*, Visualizing RNA Dynamics in Live Cells with Bright and Stable Fluorescent RNAs, Nature Biotechnology, 2019, 37: 1287-1293.

(8) Xiaopei Xu, Zhaoxia Du, Renmei Liu, Ting Li, Yuzheng Zhao, Xianjun Chen* and Yi Yang*, A Single-Component Optogenetic System Allows Stringent Switch of Gene Expression in Yeast Cells, ACS Synthetic Biology, 2018, 7: 2045-2053.

(9) Yejun Zou, Aoxue Wang , Mei Shi , Xianjun Chen , Renmei Liu , Ting Li , Chenxia Zhang , Zhuo Zhang , Linyong Zhu , Zhenyu Ju , Joseph Loscalzo , Yi Yang*, Yuzheng Zhao*, Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors, Nature protocols, 2018, 13: 2362-2386..

(10) Rongkun Tao, Yuzheng Zhao, Huanyu Chu, Aoxue Wang, Jiahuan Zhu, Xianjun Chen, Yejun Zou, Mei Shi, Renmei Liu, Ni Su, Jiulin Du, Hai-Meng Zhou, Linyong Zhu, Xuhong Qian, Haiyan Liu*, Joseph Loscalzo, and Yi Yang*, Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism, Nature Methods, 2017, 14: 720-728.

(11) Hanyang Hu, Yanfang Gu, Lei Xu, Yejun Zou, Aoxue Wang, Rongkun Tao, Xianjun Chen, Yuzheng Zhao*, and Yi Yang*. A genetically encoded toolkit for tracking live-cell histidine dynamics in space and time, Scientific Reports, 2017, 7, 43479.

(12) Wansheng Sun, Wenyao Zhang, Chao Zhang, Miuwei Mao, Yuzheng Zhao, Xianjun Chen*, and Yi Yang*, Light-induced protein degradation in human-derived cells. Biochemical and Biophysical Research Communications, 2017, 487, 241-246.

(13) Xianjun Chen, Renmei Liu, Zhengcai Ma, Xiaopei Xu., Haoqian Zhang, Jianhe Xu, Qi Ouyang, and Yi Yang*, An extraordinary stringent and sensitive light-switchable gene expression system for bacterial cells, Cell Research, 2016, 26: 854-857. (IF=15.393)

(14) Xianjun Chen^#, Ting Li^#, Xue Wang, Zengmin Du, Renmei Liu, and Yi Yang*, Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light, Nucleic Acids Research, 2016, 44: 2677-2690. (IF=11.561)

(15) Xianjun Chen, Ting Li, Xue Wang, and Yi Yang*, A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes, Biochemical and Biophysical Research Communications, 2015, 465: 769-776.

(16) Yuzheng Zhao, Qingxun Hu, Feixiong Cheng, Ni Su, Aoxue Wang, Yejun Zou, Hanyang Hu, Xianjun Chen, Hai-Meng Zhou, Xinzhi Huang, Kai Yang, Qian Zhu, Xue Wang, Jing Yi, Linyong Zhu, Xuhong Qian, Lixin Chen, Yun Tang, Joseph Loscalzo, and Yi Yang*, SoNar, a Highly Responsive NAD(+)/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents, Cell Metabolism, 2015, 21: 777-789.

(17) Xue Wang, Xianjun Chen, and Yi Yang*, Spatiotemporal control of gene expression by a light-switchable transgene system, Nature Methods, 2012, 9: 266-269.

联系方式

电话/传真：021-64251287

E-mail: xianjunchen@ecust.edu.cn

通讯地址：上海市徐汇区梅陇路130号beat365体育官网平台光遗传学与合成生物学交叉学科研究中心315室，

邮编：200237